反应详情

温度

100 °C

A suspension of ethyl 4-hydroxy-3-methyl-1-(2-pyridinyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylate (2.0 g, 6.7 mmol) in 6N hydrochloric acid solution (10 mL) was heated and stirred at 100° C. for 1 hour. The solution was cooled to room temperature, made weakly acidic by the addition of an aqueous sodium hydroxide solution, and the resulting precipitate was collected by filtration. The crude crystals thus obtained were washed with water and dried to give the title compound (0.6 g, 33% yield).

1. temperaturewas heated
2. temperatureThe solution was cooled to room temperature
3. filtrationthe resulting precipitate was collected by filtration
4. customThe crude crystals thus obtained
5. washwere washed with water
6. customdried