p-Anisoyl chloride → HCID 33783640, 화합물

반응식

[NH:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][N:4]=1)[NH2:2].[C:9]([CH2:11]C(OC(C)(C)C)=O)#[N:10].[CH3:19][O:20][C:21]1[CH:29]=[CH:28][C:24]([C:25](Cl)=O)=[CH:23][CH:22]=1>>[CH3:19][O:20][C:21]1[CH:29]=[CH:28][C:24]([C:25]2[CH:11]=[C:9]([NH2:10])[N:1]([C:3]3[CH:8]=[CH:7][CH:6]=[CH:5][N:4]=3)[N:2]=2)=[CH:23][CH:22]=1

참가 물질

반응물 3

HCID 7477p-Anisoyl chloride

HCID 70693tert-Butyl cyanoacetate

HCID 786452-Hydrazinopyridine

생성물 1

HCID 33783640HCID 33783640, 화합물수율 95%

실험 절차

Following the procedure described in Reference Example 2-4, the title compound was prepared from 2-hydrazinopyridine and 3-(4-methoxyphenyl)-3-oxypropanenitrile prepared from tert-butyl cyanoacetate and 4-methoxybenzoyl chloride according to the method described in Synthesis, p. 337 (1997) (3.48 g, 95% yield).