反应详情

A solution of m-chloroperbenzoic acid (0.96 g, 5.6 mmol) in chloroform (55 mL) was added dropwise to a solution of 3-methyl-4-propylsulfanyl-1-(2-pyridinyl)-1H-pyrazolo[3,4-b]quinoline (1.54 g, 4.6 mmol) in chloroform (55 mL) at a temperature of lower than 0° C., and the mixture was stirred at the same temperature for another 2.5 hours. The reaction solution was washed with an aqueous saturated sodium bicarbonate solution and saturated brine, and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The residue thus obtained was purified by silica gel column chromatography (hexane:chloroform:ethyl acetate=2:1:1 to 1:1:1) to give the title compound (0.84 g, 52% yield).

1. washThe reaction solution was washed with an aqueous saturated sodium bicarbonate solution and saturated brine
2. dry with materialdried over anhydrous sodium sulfate
3. customthe solvent was evaporated under reduced pressure
4. customThe residue thus obtained
5. customwas purified by silica gel column chromatography (hexane:chloroform:ethyl acetate=2:1:1 to 1:1:1)