反应详情

A solution of 3-methyl-6-nitro-1-(2-pyridinyl)-1,9-dihydro-4H-pyrazolo[3,4-b]quinolin-4-one (4.64 g, 14.4 mmol) and 5% palladium-carbon (4.64 g, 50% hydrate) in N,N-dimethylformamide (400 mL) was stirred at room temperature under hydrogen atmosphere for 4 hours. The reaction solution was filtered to remove the catalyst, and the filtrate was evaporated under reduced pressure. The residue thus obtained was purified by silica gel column chromatography (chloroform:methanol=99:1 to chloroform:methanol=95:5) to give the title compound (2.86 g, 69% yield).

1. filtrationThe reaction solution was filtered
2. customto remove the catalyst
3. customthe filtrate was evaporated under reduced pressure
4. customThe residue thus obtained
5. customwas purified by silica gel column chromatography (chloroform:methanol=99:1 to chloroform:methanol=95:5)