Hydrochloric Acid → HCID 135482311, compound

HRID 498035Notes

Reaction equation

HRID 498035 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([F:13])=[C:9]([F:12])[CH:10]=2)[N:5]=[C:4]2[N:14]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=3)[N:15]=[C:16]([CH3:17])[C:3]=12.Cl.C([OH:27])C>>[F:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][C:8]=1[F:13])[NH:5][C:4]1[N:14]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=3)[N:15]=[C:16]([CH3:17])[C:3]=1[C:2]2=[O:27]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 22320246HCID 22320246, compound

Product 1

HCID 135482311HCID 135482311, compoundYield 99%

Procedure

To a solution of 4-chloro-6,7-difluoro-3-methyl-1-(2-pyridinyl)-1H-pyrazolo[3,4-b]quinoline (2.21 g, 6.68 mmol) in ethanol (120 mL), 6N hydrochloric acid (6 mL, 36.0 mmol) was added and the mixture was heated under reflux for 3 hours. The solution was allowed to cool to room temperature, and the resulting crystals were collected by filtration. The crystals were washed with ethanol and air dried to give the title compound (2.08 g, 99% yield).

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 3 hours
  3. filtrationthe resulting crystals were collected by filtration
  4. washThe crystals were washed with ethanol and air
  5. customdried

Sources & evidence

ORD record
ord-974d0cf09a2a41c18d30d3a0dfa66f65
Source dataset
uspto-grants-2005_09
Patent number
US06949648B2

Reaction notes

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