反应详情

To a solution of 4-chloro-6,7-difluoro-1-(2-pyridinyl)-1H-pyrazolo[3,4-b]quinoline (3.17 g, 10.0 mmol) in ethanol (160 mL) was added 6 N hydrochloric acid (8 mL, 48.0 mmol), and the mixture was heated under reflux for 6 hours. The solution was allowed to cool to room temperature, and the resulting crystals were collected by filtration. The crystals were washed with ethanol, air dried, and subsequently recrystallized from ethanol to give the title compound (2.47 g, 83% yield).

1. temperaturethe mixture was heated
2. temperatureunder reflux for 6 hours
3. filtrationthe resulting crystals were collected by filtration
4. washThe crystals were washed with ethanol, air
5. customdried
6. customsubsequently recrystallized from ethanol