Hydrochloric Acid → HCID 135848047, compound

HRID 498059Notes

Reaction equation

HRID 498059 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([F:13])=[C:9]([F:12])[CH:10]=2)[N:5]=[C:4]2[N:14]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=3)[N:15]=[CH:16][C:3]=12.Cl.C([OH:26])C>>[F:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][C:8]=1[F:13])[NH:5][C:4]1[N:14]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=3)[N:15]=[CH:16][C:3]=1[C:2]2=[O:26]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 22320244HCID 22320244, compound

Product 1

HCID 135848047HCID 135848047, compoundYield 83%

Procedure

To a solution of 4-chloro-6,7-difluoro-1-(2-pyridinyl)-1H-pyrazolo[3,4-b]quinoline (3.17 g, 10.0 mmol) in ethanol (160 mL) was added 6 N hydrochloric acid (8 mL, 48.0 mmol), and the mixture was heated under reflux for 6 hours. The solution was allowed to cool to room temperature, and the resulting crystals were collected by filtration. The crystals were washed with ethanol, air dried, and subsequently recrystallized from ethanol to give the title compound (2.47 g, 83% yield).

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 6 hours
  3. filtrationthe resulting crystals were collected by filtration
  4. washThe crystals were washed with ethanol, air
  5. customdried
  6. customsubsequently recrystallized from ethanol

Sources & evidence

ORD record
ord-0c0a52d2352e456ebfea6864ffec8b64
Source dataset
uspto-grants-2005_09
Patent number
US06949648B2

Reaction notes

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