Hydrochloric Acid → HCID 135418254, compound

HRID 498061Notes

Reaction equation

HRID 498061 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([F:13])=[C:9]([F:12])[CH:10]=2)[N:5]=[C:4]2[N:14]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=3)[N:15]=[C:16]([CH2:17][CH3:18])[C:3]=12.Cl.C([OH:28])C>>[CH2:17]([C:16]1[C:3]2[C:2](=[O:28])[C:11]3[C:6](=[CH:7][C:8]([F:13])=[C:9]([F:12])[CH:10]=3)[NH:5][C:4]=2[N:14]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)[N:15]=1)[CH3:18]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 22320316HCID 22320316, compound

Product 1

HCID 135418254HCID 135418254, compoundYield 73%

Procedure

To a solution of 4-chloro-3-ethyl-6,7-difluoro-1-(2-pyridinyl)-1H-pyrazolo[3,4-b]quinoline (2.49 g, 7.22 mmol) in ethanol (120 mL), 6N hydrochloric acid (6 mL, 36.0 mmol) was added and the mixture was heated under reflux for 6 hours. The solution was allowed to cool to room temperature, and the resulting crystals were collected by filtration. The crystals were washed with ethanol, air dried, and recrystallized from ethanol to give the title compound (1.73 g, 73% yield).

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 6 hours
  3. filtrationthe resulting crystals were collected by filtration
  4. washThe crystals were washed with ethanol, air
  5. customdried
  6. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-71c377a73e0341a5b622dd39f848a897
Source dataset
uspto-grants-2005_09
Patent number
US06949648B2

Reaction notes

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