Hydrochloric Acid → HCID 135848100, compound

HRID 498063Notes

Reaction equation

HRID 498063 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([F:13])=[C:9]([F:12])[CH:10]=2)[N:5]=[C:4]2[N:14]([C:18]3[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=3)[N:15]=[C:16]([CH3:17])[C:3]=12.[ClH:24].C([OH:27])C>>[ClH:1].[ClH:24].[F:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][C:8]=1[F:13])[NH:5][C:4]1[N:14]([C:18]3[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=3)[N:15]=[C:16]([CH3:17])[C:3]=1[C:2]2=[O:27]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 22320221HCID 22320221, compound

Product 1

HCID 135848100HCID 135848100, compoundYield 33%

Procedure

To a solution of 4-chloro-6,7-difluoro-3-methyl-1-(3-pyridinyl)-1H-pyrazolo[3,4-b]quinoline (0.70 g, 2.12 mmol) in ethanol (40 mL), 6N hydrochloric acid (2 mL, 12.0 mmol) was added, and the mixture was heated under reflux for 2.5 days. The solution was allowed to cool to room temperature, and the resulting crystals were collected by filtration. The crystals were washed with ethanol and air dried to give the title compound (0.27 g, 33% yield).

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 2.5 days
  3. filtrationthe resulting crystals were collected by filtration
  4. washThe crystals were washed with ethanol and air
  5. customdried

Sources & evidence

ORD record
ord-68031c9b308f4295ba3842752c873fdf
Source dataset
uspto-grants-2005_09
Patent number
US06949648B2

Reaction notes

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