Hydrochloric Acid → HCID 135848061, compound

HRID 498065Notes

Reaction equation

HRID 498065 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([F:13])=[C:9]([F:12])[CH:10]=2)[N:5]=[C:4]2[N:14]([C:18]3[CH:23]=[CH:22][N:21]=[CH:20][CH:19]=3)[N:15]=[C:16]([CH3:17])[C:3]=12.[ClH:24].C([OH:27])C>>[ClH:1].[ClH:24].[F:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][C:8]=1[F:13])[NH:5][C:4]1[N:14]([C:18]3[CH:23]=[CH:22][N:21]=[CH:20][CH:19]=3)[N:15]=[C:16]([CH3:17])[C:3]=1[C:2]2=[O:27]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 22320157HCID 22320157, compound

Product 1

HCID 135848061HCID 135848061, compoundYield 55%

Procedure

To a solution of 4-chloro-6,7-difluoro-3-methyl-1-(4-pyridinyl)-1H-pyrazolo[3,4-b]quinoline (0.80 g, 2.42 mmol) in ethanol (40 mL), 6N hydrochloric acid (2 mL, 12.0 mmol) was added, and the mixture was heated under reflux for 6 hours. The solution was allowed to cool to room temperature, and the resulting crystals were collected by filtration. The crystals were washed with ethanol, air dried and recrystallized from ethanol to give the title compound (0.51 g, 55% yield).

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 6 hours
  3. filtrationthe resulting crystals were collected by filtration
  4. washThe crystals were washed with ethanol, air
  5. customdried
  6. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-58de705d799c41e58d43f03b1a6fbee6
Source dataset
uspto-grants-2005_09
Patent number
US06949648B2

Reaction notes

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