Hydrochloric Acid → HCID 135848110, compound

HRID 498070Notes

Reaction equation

HRID 498070 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]2[N:12]([C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([CH3:22])[N:17]=3)[N:13]=[C:14]([CH3:15])[C:3]=12.Cl.C([OH:26])C>>[CH3:15][C:14]1[C:3]2[C:2](=[O:26])[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[NH:5][C:4]=2[N:12]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([CH3:22])[N:17]=2)[N:13]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 22320337HCID 22320337, compound

Product 1

HCID 135848110HCID 135848110, compoundYield 82%

Procedure

To a solution of 4-chloro-3-methyl-1-(6-methyl-2-pyridinyl)-1H-pyrazolo[3,4-b]quinoline (2.00 g, 6.48 mmol) in ethanol (90 mL), 6N hydrochloric acid (3 mL, 18.0 mmol) was added and the mixture was heated under reflux for 4 hours. The reaction solution was allowed to cool to room temperature, and the resulting crystals were collected by filtration. The crystals were washed with ethanol, air dried, and recrystallized from ethanol to give the title compound (1.55 g, 82% yield).

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 4 hours
  3. filtrationthe resulting crystals were collected by filtration
  4. washThe crystals were washed with ethanol, air
  5. customdried
  6. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-31c94a7da8404d2791999d6ed6f7299b
Source dataset
uspto-grants-2005_09
Patent number
US06949648B2

Reaction notes

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