HCID 131725171, compound → HCID 131725173, compound

HRID 498106Notes

Reaction equation

HRID 498106 reaction equation
[C:1]([CH:5]1[CH2:12][CH2:11][CH2:10][C:9](=[CH:13][CH2:14][OH:15])[CH:8]([O:16][SiH:17]([CH3:19])[CH3:18])[CH2:7][CH2:6]1)([CH3:4])([CH3:3])[CH3:2]>ClCCl.[O-2].[O-2].[Mn+4]>[C:1]([CH:5]1[CH2:12][CH2:11][CH2:10][C:9](=[CH:13][CH:14]=[O:15])[CH:8]([O:16][SiH:17]([CH3:19])[CH3:18])[CH2:7][CH2:6]1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 131725171HCID 131725171, compound

Product 1

HCID 131725173HCID 131725173, compoundYield 77.5%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

3.9 g of the above product (b) was dissolved in 150 ml of dichloromethane. To the solution was added 44 g of manganese dioxide while stirring at room temperature. After completion of adding the reagent, the reaction solution was stirred at room temperature for three days. The reaction solution was filtered and the filtrate was concentrated to afford 3.0 g of the titled product (c) as a colorless oily matter.

Workup

  1. additionAfter completion of adding the reagent
  2. stirringthe reaction solution was stirred at room temperature for three days
  3. filtrationThe reaction solution was filtered
  4. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-4a0c16aa9866426bafc2d116c8ff506b
Source dataset
uspto-grants-2005_09
Patent number
US06949585B2

Reaction notes

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