(4-Methoxy-2-nitro-phenyl)-carbamic acid tert-butyl ester → tert-butyl N-(2-amino-4-methoxyphenyl)carbamate

HRID 498196Notes

Reaction equation

HRID 498196 reaction equation
[C:1]([O:5][C:6](=[O:19])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][C:9]=1[N+:16]([O-])=O)([CH3:4])([CH3:3])[CH3:2]>[Pd]>[C:1]([O:5][C:6](=[O:19])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][C:9]=1[NH2:16])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 1

HCID 10730597(4-Methoxy-2-nitro-phenyl)-carbamic acid tert-butyl ester

Product 1

HCID 10752410tert-butyl N-(2-amino-4-methoxyphenyl)carbamate

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

The title compound was prepared from (4-methoxy-2-nitro-phenyl)-carbamic acid tert-butyl ester (Example A10) by hydrogenation with 10% Pd/C according to the general procedure J (method a). Obtained as a white solid (19.377 g).

Sources & evidence

ORD record
ord-ee5cf85b8e56467cbb1d1bdafadded88
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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