tert-Butyl (5-methoxy-2-nitrophenyl)carbamate → N1-Boc-5-methoxy-1,2-benzenediamine

HRID 498199Notes

Reaction equation

HRID 498199 reaction equation
[C:1]([O:5][C:6](=[O:19])[NH:7][C:8]1[CH:13]=[C:12]([O:14][CH3:15])[CH:11]=[CH:10][C:9]=1[N+:16]([O-])=O)([CH3:4])([CH3:3])[CH3:2]>[Pd]>[C:1]([O:5][C:6](=[O:19])[NH:7][C:8]1[CH:13]=[C:12]([O:14][CH3:15])[CH:11]=[CH:10][C:9]=1[NH2:16])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 1

HCID 10199249tert-Butyl (5-methoxy-2-nitrophenyl)carbamate

Product 1

HCID 51358605N1-Boc-5-methoxy-1,2-benzenediamine

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

The title compound was prepared from (5-methoxy-2-nitro-phenyl)-carbamic acid tert-butyl ester (Example A12) (12.234 g, 45.6 mmol) by hydrogenation with 10% Pd/C according to the general procedure J (method a). Obtained as a purple solid (7.185 g).

Sources & evidence

ORD record
ord-0b03df718d2a4d34bd714fc7d85bf828
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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