tert-Butyl (5-morpholino-2-nitro-4-(trifluoromethyl)phenyl)carbamate → HCID 12048026, compound

HRID 498215Notes

Reaction equation

HRID 498215 reaction equation
[C:1]([O:5][C:6](=[O:27])[NH:7][C:8]1[CH:13]=[C:12]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[C:11]([C:20]([F:23])([F:22])[F:21])=[CH:10][C:9]=1[N+:24]([O-])=O)([CH3:4])([CH3:3])[CH3:2]>[Pd]>[C:1]([O:5][C:6](=[O:27])[NH:7][C:8]1[CH:13]=[C:12]([N:14]2[CH2:15][CH2:16][O:17][CH2:18][CH2:19]2)[C:11]([C:20]([F:21])([F:22])[F:23])=[CH:10][C:9]=1[NH2:24])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 1

HCID 12048025tert-Butyl (5-morpholino-2-nitro-4-(trifluoromethyl)phenyl)carbamate

Product 1

HCID 12048026HCID 12048026, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

The title compound was prepared from (5-morpholin-4-yl-2-nitro-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example C8) (1.83 g, 4.68 mmol) by hydrogenation with 10% Pd/C according to the general procedure J (method a). Obtained as an amorphous red substance (1.72 g, 102%).

Workup

  1. customObtained as an amorphous red substance (1.72 g, 102%)

Sources & evidence

ORD record
ord-4d58bfc80f50422db21c9243c0945645
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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