[4-Chloro-2-nitro-5-(2,2,2-trifluoro-ethoxy)-phenyl]-carbamic acid tert-butyl ester → Carbamic acid,[2-amino-4-chloro-5-(2,2,2-trifluoroethoxy)phenyl]-,1,1-dimethylethyl ester

HRID 498218Notes

Reaction equation

HRID 498218 reaction equation
[C:1]([O:5][C:6](=[O:24])[NH:7][C:8]1[CH:13]=[C:12]([O:14][CH2:15][C:16]([F:19])([F:18])[F:17])[C:11]([Cl:20])=[CH:10][C:9]=1[N+:21]([O-])=O)([CH3:4])([CH3:3])[CH3:2]>[Pt]>[C:1]([O:5][C:6](=[O:24])[NH:7][C:8]1[CH:13]=[C:12]([O:14][CH2:15][C:16]([F:19])([F:17])[F:18])[C:11]([Cl:20])=[CH:10][C:9]=1[NH2:21])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 1

HCID 69489704[4-Chloro-2-nitro-5-(2,2,2-trifluoro-ethoxy)-phenyl]-carbamic acid tert-butyl ester

Product 1

HCID 69486817Carbamic acid,[2-amino-4-chloro-5-(2,2,2-trifluoroethoxy)phenyl]-,1,1-dimethylethyl ester

Reagents, catalysts & solvents 1

HCID 23939PlatinumCatalyst

Procedure

The title compound was prepared from ([4-chloro-2-nitro-5-(2,2,2-trifluoro-ethoxy)-phenyl]-carbamic acid tert-butyl ester (Example A25) (8.70 g, 23.5 mmol) by hydrogenation with 5% Pt/C according to the general procedure J (method a). Obtained as a yellow solid (7.94 g, 99%).

Sources & evidence

ORD record
ord-f7674975cabb460faacdfed09334bf1d
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

Loading…