3-Oxo-3-(3-pyridin-4-yl-phenyl)-propionic acid tert-butyl ester → {2-Dimethylamino-2'-fluoro-5-(3-oxo-3-(3-pyridin-4-yl-phenyl)-propionylamino]-biphenyl-4-yl}-carbamic acid tert-butyl ester

HRID 498287Notes

Reaction equation

HRID 498287 reaction equation
[C:1]([O:5][C:6](=[O:25])[NH:7][C:8]1[C:13]([NH2:14])=[CH:12][C:11]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[F:21])=[C:10]([N:22]([CH3:24])[CH3:23])[CH:9]=1)([CH3:4])([CH3:3])[CH3:2].C([O:30][C:31](=O)[CH2:32][C:33](=[O:46])[C:34]1[CH:39]=[CH:38][CH:37]=[C:36]([C:40]2[CH:45]=[CH:44][N:43]=[CH:42][CH:41]=2)[CH:35]=1)(C)(C)C>>[C:1]([O:5][C:6](=[O:25])[NH:7][C:8]1[C:13]([NH:14][C:31](=[O:30])[CH2:32][C:33](=[O:46])[C:34]2[CH:39]=[CH:38][CH:37]=[C:36]([C:40]3[CH:41]=[CH:42][N:43]=[CH:44][CH:45]=3)[CH:35]=2)=[CH:12][C:11]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[F:21])=[C:10]([N:22]([CH3:23])[CH3:24])[CH:9]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 694868533-Oxo-3-(3-pyridin-4-yl-phenyl)-propionic acid tert-butyl esterHCID 69489440HCID 69489440, compound

Product 1

HCID 86589252{2-Dimethylamino-2'-fluoro-5-(3-oxo-3-(3-pyridin-4-yl-phenyl)-propionylamino]-biphenyl-4-yl}-carbamic acid tert-butyl ester

Procedure

The title compound was prepared from (5-amino-2-dimethylamino-2′-fluoro-biphenyl-4-yl)-carbamic acid tert-butyl ester (Example J10) (271 mg, 0.78 mmol) and 3-oxo-3-(3-pyridin-4-yl-phenyl)-propionic acid tert-butyl ester (Example K2) (194 mg, 0.65 mmol) according to the general procedure M. Obtained as a yellow solid (316 mg).

Sources & evidence

ORD record
ord-9bfeaf62b70443d7b10add9e4e5511fb
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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