HRID498289

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID67361423

未命名化合物

结构：COc1ccc(-c2cccc(C(=O)CC(=O)OC(C)(C)C)c2)nn1

HCID69486831

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(-c2cccc(C(=O)CC(=O)Nc3cc(-c4ccccc4F)ccc3NC(=O)OC(C)(C)C)c2)nn1

HCID86589254

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from (3-amino-2′-fluoro-biphenyl-4-yl)-carbamic acid tert-butyl ester [CAS-No. 335255-65-7] (227 mg, 0.75 mmol) and 3-[3-(6-methoxy-pyridazin-3-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester (Example K7) (246 mg, 0.75 mmol) according to the general procedure M. Obtained as an off-white amorphous substance (352 mg).

WORKUP

后处理

customObtained as an off-white amorphous substance (352 mg)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e12602c7a2604b058375d1f0d0698b63
来源数据集: uspto-grants-2005_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06949542B2
来源说明: uspto-grants-2005_09

反应 SMILES

[C:1]([O:5][C:6](=[O:22])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[F:20])=[CH:10][C:9]=1[NH2:21])([CH3:4])([CH3:3])[CH3:2].C([O:27][C:28](=O)[CH2:29][C:30]([C:32]1[CH:37]=[CH:36][CH:35]=[C:34]([C:38]2[N:39]=[N:40][C:41]([O:44][CH3:45])=[CH:42][CH:43]=2)[CH:33]=1)=[O:31])(C)(C)C>>[C:1]([O:5][C:6](=[O:22])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[F:20])=[CH:10][C:9]=1[NH:21][C:28](=[O:27])[CH2:29][C:30]([C:32]1[CH:37]=[CH:36][CH:35]=[C:34]([C:38]2[N:39]=[N:40][C:41]([O:44][CH3:45])=[CH:42][CH:43]=2)[CH:33]=1)=[O:31])([CH3:4])([CH3:2])[CH3:3]