3-Oxo-3-(3-pyridin-3-yl-phenyl)-propionic acid tert-butyl ester → {5-Ethoxy-2-[3-oxo-3-(3-pyridin-3-yl-phenyl)-propionylamino]-phenyl}-carbamic acid tert-butyl ester

HRID 498364Notes

Reaction equation

HRID 498364 reaction equation
[C:1]([O:5][C:6](=[O:18])[NH:7][C:8]1[CH:13]=[C:12]([O:14][CH2:15][CH3:16])[CH:11]=[CH:10][C:9]=1[NH2:17])([CH3:4])([CH3:3])[CH3:2].C([O:23][C:24](=O)[CH2:25][C:26](=[O:39])[C:27]1[CH:32]=[CH:31][CH:30]=[C:29]([C:33]2[CH:34]=[N:35][CH:36]=[CH:37][CH:38]=2)[CH:28]=1)(C)(C)C>>[C:1]([O:5][C:6](=[O:18])[NH:7][C:8]1[CH:13]=[C:12]([O:14][CH2:15][CH3:16])[CH:11]=[CH:10][C:9]=1[NH:17][C:24](=[O:23])[CH2:25][C:26](=[O:39])[C:27]1[CH:32]=[CH:31][CH:30]=[C:29]([C:33]2[CH:34]=[N:35][CH:36]=[CH:37][CH:38]=2)[CH:28]=1)([CH3:2])([CH3:4])[CH3:3]

Participants

3

Reactant 2

HCID 112664733-Oxo-3-(3-pyridin-3-yl-phenyl)-propionic acid tert-butyl esterHCID 69486521HCID 69486521, compound

Product 1

HCID 86589329{5-Ethoxy-2-[3-oxo-3-(3-pyridin-3-yl-phenyl)-propionylamino]-phenyl}-carbamic acid tert-butyl ester

Procedure

The title compound was prepared from (2-amino-5-ethoxy-phenyl)-carbamic acid tert-butyl ester (Example J14) (194 mg, 0.77 mmol) and 3-oxo-3-(3-pyridin-3-yl-phenyl)-propionic acid tert-butyl ester (Example K1) (224 mg, 0.75 mmol) according to the general procedure M. Obtained as a light yellow foam (203 mg, 55%).

Sources & evidence

ORD record
ord-a3235c28375c405cb6f451caadd31006
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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