HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 3-Nitro-n-[1-(4-pyridyl)piperidin-4-ylmethyl]pyridine-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Chloro-3-nitropyridine | HCID 79613 | — |
| Reactant | [1-(Pyridin-4-yl)piperidin-4-yl]methanamine | HCID 10607746 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-Nitro-n-[1-(4-pyridyl)piperidin-4-ylmethyl]pyridine-2-amine | HCID 23497755 | 60% |
Reaction Steps
A solution of 2-chloro-3-nitropyridine (290 mg, 1.83 mmol), triethylamine (0.26 mL) and 1-(4-pyridyl)-piperidine-4-methylamine (350 mg, 1.83 mmol) in EtOH (10 mL) was heated at reflux. After 17 h, the mixture was concentrated and the residue was purified by chromatography (SiO2, 2 to 4% (2 N NH3 in methanol) in chloroform) yielding 340 mg (60%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06710057B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-665127de5f8643a696f7c88b4a06e24c |
| Source note | uspto-grants-2004_03 |