反应详情

A solution of 2-chloro-3-nitropyridine (290 mg, 1.83 mmol), triethylamine (0.26 mL) and 1-(4-pyridyl)-piperidine-4-methylamine (350 mg, 1.83 mmol) in EtOH (10 mL) was heated at reflux. After 17 h, the mixture was concentrated and the residue was purified by chromatography (SiO2, 2 to 4% (2 N NH3 in methanol) in chloroform) yielding 340 mg (60%) of the title compound.

1. temperatureat reflux
2. concentrationthe mixture was concentrated
3. customthe residue was purified by chromatography (SiO2, 2 to 4% (2 N NH3 in methanol) in chloroform)