3-[3-(6-Cyclopropyl-pyridin-3-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester → HCID 86589380, compound

HRID 498415Notes

Reaction equation

HRID 498415 reaction equation
[C:1]([O:5][C:6](=[O:23])[NH:7][C:8]1[CH:13]=[C:12]([O:14][CH2:15][CH2:16][CH3:17])[C:11]([C:18]([F:21])([F:20])[F:19])=[CH:10][C:9]=1[NH2:22])([CH3:4])([CH3:3])[CH3:2].C([O:28][C:29](=O)[CH2:30][C:31]([C:33]1[CH:38]=[CH:37][CH:36]=[C:35]([C:39]2[CH:40]=[N:41][C:42]([CH:45]3[CH2:47][CH2:46]3)=[CH:43][CH:44]=2)[CH:34]=1)=[O:32])(C)(C)C>>[C:1]([O:5][C:6](=[O:23])[NH:7][C:8]1[CH:13]=[C:12]([O:14][CH2:15][CH2:16][CH3:17])[C:11]([C:18]([F:21])([F:20])[F:19])=[CH:10][C:9]=1[NH:22][C:29](=[O:28])[CH2:30][C:31]([C:33]1[CH:38]=[CH:37][CH:36]=[C:35]([C:39]2[CH:40]=[N:41][C:42]([CH:45]3[CH2:46][CH2:47]3)=[CH:43][CH:44]=2)[CH:34]=1)=[O:32])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 694893843-[3-(6-Cyclopropyl-pyridin-3-yl)-phenyl]-3-oxo-propionic acid tert-butyl esterHCID 69489890HCID 69489890, compound

Product 1

HCID 86589380HCID 86589380, compound

Procedure

The title compound was prepared from (2-amino-5-propoxy-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example J35) (251 mg, 0.75 mmol) and 3-[3-(6-cyclo-propyl-pyridin-3-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester (Example K21) (253 mg, 0.75 mmol) according to the general procedure M. Obtained as a yellow foam (372 mg, 83%).

Sources & evidence

ORD record
ord-5398b269ff9148168806827ed26f5123
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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