3-[3-(2,6-Dimethyl-pyridin-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester → HCID 86589383, compound

HRID 498418Notes

Reaction equation

HRID 498418 reaction equation
[C:1]([O:5][C:6](=[O:23])[NH:7][C:8]1[CH:13]=[C:12]([O:14][CH2:15][CH2:16][CH3:17])[C:11]([C:18]([F:21])([F:20])[F:19])=[CH:10][C:9]=1[NH2:22])([CH3:4])([CH3:3])[CH3:2].C([O:28][C:29](=O)[CH2:30][C:31]([C:33]1[CH:38]=[CH:37][CH:36]=[C:35]([C:39]2[CH:44]=[C:43]([CH3:45])[N:42]=[C:41]([CH3:46])[CH:40]=2)[CH:34]=1)=[O:32])(C)(C)C>>[C:1]([O:5][C:6](=[O:23])[NH:7][C:8]1[CH:13]=[C:12]([O:14][CH2:15][CH2:16][CH3:17])[C:11]([C:18]([F:21])([F:20])[F:19])=[CH:10][C:9]=1[NH:22][C:29](=[O:28])[CH2:30][C:31]([C:33]1[CH:38]=[CH:37][CH:36]=[C:35]([C:39]2[CH:40]=[C:41]([CH3:46])[N:42]=[C:43]([CH3:45])[CH:44]=2)[CH:34]=1)=[O:32])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 694892403-[3-(2,6-Dimethyl-pyridin-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl esterHCID 69489890HCID 69489890, compound

Product 1

HCID 86589383HCID 86589383, compound

Procedure

The title compound was prepared from (2-amino-5-propoxy-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example J35) (251 mg, 0.75 mmol) and 3-[3-(2,6-dimethyl-pyridin-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester (Example K15) (244 mg, 0.75 mmol) according to the general procedure M. Obtained as a light yellow solid (172 mg, 49%).

Sources & evidence

ORD record
ord-02a985de74054f02a7a01c36ba5c8932
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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