HCID 69486907, compound → HCID 86589438, compound

HRID 498473Notes

Reaction equation

HRID 498473 reaction equation
[C:1]([O:5][C:6](=[O:17])[NH:7][C:8]1[CH:13]=[C:12]([CH3:14])[C:11]([Cl:15])=[CH:10][C:9]=1[NH2:16])([CH3:4])([CH3:3])[CH3:2].C([O:22][C:23](=O)[CH2:24][C:25](=[O:46])[C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([C:32]2[CH:37]=[CH:36][N:35]=[C:34]([CH2:38][O:39][CH:40]3[CH2:45][CH2:44][CH2:43][CH2:42][O:41]3)[CH:33]=2)[CH:27]=1)(C)(C)C>>[C:1]([O:5][C:6](=[O:17])[NH:7][C:8]1[CH:13]=[C:12]([CH3:14])[C:11]([Cl:15])=[CH:10][C:9]=1[NH:16][C:23](=[O:22])[CH2:24][C:25](=[O:46])[C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([C:32]2[CH:37]=[CH:36][N:35]=[C:34]([CH2:38][O:39][CH:40]3[CH2:45][CH2:44][CH2:43][CH2:42][O:41]3)[CH:33]=2)[CH:27]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 69486907HCID 69486907, compoundHCID 69486983tert-Butyl (2-amino-4-chloro-5-methylphenyl)carbamate

Product 1

HCID 86589438HCID 86589438, compound

Procedure

The title compound was prepared from (2-amino-4-chloro-5-methyl-phenyl)-carbamic acid tert-butyl ester (Example J22) (257 mg, 1.0 mmol) and (RS)-3-oxo-3-{3-[2-(tetrahydro-pyran-2-yloxymethyl)-pyridin-4-yl]-phenyl}-propionic acid tert-butyl ester (Example K40) (412 mg, 1.0 mmol) according to the general procedure M. Obtained as a light brown solid (510 mg, 86%).

Sources & evidence

ORD record
ord-03c7902696114bdda7766f09fe7fe815
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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