HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 8-(2-Fluoro-phenyl)-4-[3-(6-methyl-pyridazin-3-yl)-phenyl]-1,3-dihydro-benzo[b][1,4]diazepin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (2'-Fluoro-3-{3-[3-(6-methyl-pyridazin-3-yl)-phenyl]-3-oxo-propionylamino}-biphenyl-4-yl)-carbamic acid tert-butyl ester | HCID 86589232 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 8-(2-Fluoro-phenyl)-4-[3-(6-methyl-pyridazin-3-yl)-phenyl]-1,3-dihydro-benzo[b][1,4]diazepin-2-one | HCID 22317942 | — |
Reaction Steps
The title compound was prepared from (2′-fluoro-3-{3-[3-(6-methyl-pyridazin-3-yl)-phenyl]-3-oxo-propionylamino}-biphenyl-4-yl)-carbamic acid tert-butyl ester (Example M13) (292 mg, 0.541 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a light yellow solid (181 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06949542B2 |
| Source dataset | uspto-grants-2005_09 |
| ORD ID | ord-f9be308d946c4c9e8deea6128733aad1 |
| Source note | uspto-grants-2005_09 |