Trifluoroacetic acid → HCID 11442995, compound

HRID 498527Notes

Reaction equation

HRID 498527 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12](OCC(F)(F)F)[C:11]([C:20]([F:23])([F:22])[F:21])=[CH:10][C:9]=1[NH:24][C:25](=[O:41])[CH2:26][C:27](=O)[C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([C:34]2[CH:35]=[N:36][CH:37]=[CH:38][CH:39]=2)[CH:29]=1)(C)(C)C.[C:43](O)([C:45]([F:48])([F:47])[F:46])=[O:44]>C(Cl)Cl>[N:36]1[CH:37]=[CH:38][CH:39]=[C:34]([C:30]2[CH:29]=[C:28]([C:27]3[CH2:26][C:25](=[O:41])[NH:24][C:9]4[CH:10]=[C:11]([C:20]([F:23])([F:22])[F:21])[C:12]([O:44][CH2:43][C:45]([F:48])([F:47])[F:46])=[CH:13][C:8]=4[N:7]=3)[CH:33]=[CH:32][CH:31]=2)[CH:35]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86589244HCID 86589244, compound

Product 1

HCID 11442995HCID 11442995, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from [2-[3-oxo-3-(3-pyridin-3-yl-phenyl)-propionylamino]-5-(2,2,2-trifluoro-ethoxy)-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester (Example M27) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a white solid (173 mg).

Sources & evidence

ORD record
ord-bd2dbe72e72848858f6c2f1951f8b650
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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