Trifluoroacetic acid → HCID 22317694, compound

HRID 498530Notes

Reaction equation

HRID 498530 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][C:9]=1[NH:18][C:19](=[O:35])[CH2:20][C:21](=O)[C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][N:29]=2)[CH:23]=1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[N:29]1[CH:30]=[CH:31][CH:32]=[CH:33][C:28]=1[C:24]1[CH:23]=[C:22]([C:21]2[CH2:20][C:19](=[O:35])[NH:18][C:9]3[CH:10]=[C:11]([C:14]([F:17])([F:16])[F:15])[CH:12]=[CH:13][C:8]=3[N:7]=2)[CH:27]=[CH:26][CH:25]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86589247HCID 86589247, compound

Product 1

HCID 22317694HCID 22317694, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from {2-[3-oxo-3-(3-pyridin-2-yl-phenyl)-propionylamino]-4-trifluoromethyl-phenyl}-carbamic acid tert-butyl ester (Example M30) (275 mg, 0.551 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a white solid (141 mg).

Sources & evidence

ORD record
ord-6019ba110816484a856475156b15aa30
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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