Trifluoroacetic acid → HCID 22317408, compound

HRID 498546Notes

Reaction equation

HRID 498546 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([CH3:14])[C:11]([C:15]([F:18])([F:17])[F:16])=[CH:10][C:9]=1[NH:19][C:20](=[O:36])[CH2:21][C:22](=O)[C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([C:29]2[CH:34]=[CH:33][N:32]=[N:31][CH:30]=2)[CH:24]=1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:14][C:12]1[C:11]([C:15]([F:16])([F:17])[F:18])=[CH:10][C:9]2[NH:19][C:20](=[O:36])[CH2:21][C:22]([C:23]3[CH:28]=[CH:27][CH:26]=[C:25]([C:29]4[CH:34]=[CH:33][N:32]=[N:31][CH:30]=4)[CH:24]=3)=[N:7][C:8]=2[CH:13]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86589473HCID 86589473, compound

Product 1

HCID 22317408HCID 22317408, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from {5-methyl-2-[3-oxo-3-(3-pyridazin-4-yl-phenyl)-propionylamino]-4-trifluoromethyl-phenyl}-carbamic acid tert-butyl ester (Example M45) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a white solid (110 mg).

Sources & evidence

ORD record
ord-1b814cded30349c0974ba06f315d34da
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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