Trifluoroacetic acid → HCID 22317850, compound

HRID 498547Notes

Reaction equation

HRID 498547 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11](Cl)=[CH:10][C:9]=1[NH:15][C:16](=[O:34])[CH2:17][C:18]([C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([C:26]2[CH:27]=[N:28][C:29]([O:32][CH3:33])=[CH:30][CH:31]=2)[CH:21]=1)=O)(C)(C)C.C(O)([C:38]([F:41])([F:40])[F:39])=O>C(Cl)Cl>[CH3:33][O:32][C:29]1[N:28]=[CH:27][C:26]([C:22]2[CH:21]=[C:20]([C:18]3[CH2:17][C:16](=[O:34])[NH:15][C:9]4[CH:10]=[C:11]([C:38]([F:41])([F:40])[F:39])[CH:12]=[CH:13][C:8]=4[N:7]=3)[CH:25]=[CH:24][CH:23]=2)=[CH:31][CH:30]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86589474HCID 86589474, compound

Product 1

HCID 22317850HCID 22317850, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from (4-chloro-2-{3-[3-(6-methoxy-pyridin-3-yl)-phenyl]-3-oxo-propionylamino}-phenyl)-carbamic acid tert-butyl ester (Example M46) (270 mg, 0.54 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as an off-white solid (79 mg).

Sources & evidence

ORD record
ord-dc1ac23c7bd64cf59ab6572a17f60a3a
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

Loading…