Trifluoroacetic acid → HCID 22317219, compound

HRID 498556Notes

Reaction equation

HRID 498556 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([O:14][CH2:15][CH3:16])[CH:11]=[CH:10][C:9]=1[NH:17][C:18](=[O:35])[CH2:19][C:20]([C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([C:28]2[CH:33]=[CH:32][N:31]=[C:30]([CH3:34])[CH:29]=2)[CH:23]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH2:15]([O:14][C:12]1[CH:11]=[CH:10][C:9]2[NH:17][C:18](=[O:35])[CH2:19][C:20]([C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([C:28]4[CH:33]=[CH:32][N:31]=[C:30]([CH3:34])[CH:29]=4)[CH:23]=3)=[N:7][C:8]=2[CH:13]=1)[CH3:16]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86589477HCID 86589477, compound

Product 1

HCID 22317219HCID 22317219, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from (5-ethoxy-2-{3-[3-(2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionylamino}-phenyl)-carbamic acid tert-butyl ester (Example M55) (213 mg, 0.44 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a yellow solid (120 mg).

Sources & evidence

ORD record
ord-ebdfa0013f0c4aa18794bddf83dddedb
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

Loading…