Trifluoroacetic acid → HCID 11442010, compound

HRID 498557Notes

Reaction equation

HRID 498557 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([O:14][CH2:15][CH3:16])C(C(F)(F)F)=[CH:10][C:9]=1[NH:21][C:22](=[O:39])[CH2:23][C:24]([C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([C:32]2[CH:37]=[CH:36][N:35]=[C:34]([CH3:38])[CH:33]=2)[CH:27]=1)=O)(C)(C)C.[C:41](O)([C:43]([F:46])([F:45])[F:44])=O>C(Cl)Cl>[CH2:15]([O:14][C:12]1[C:41]([C:43]([F:46])([F:45])[F:44])=[CH:10][C:9]2[NH:21][C:22](=[O:39])[CH2:23][C:24]([C:26]3[CH:31]=[CH:30][CH:29]=[C:28]([C:32]4[CH:37]=[CH:36][N:35]=[C:34]([CH3:38])[CH:33]=4)[CH:27]=3)=[N:7][C:8]=2[CH:13]=1)[CH3:16]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86589267HCID 86589267, compound

Product 1

HCID 11442010HCID 11442010, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from (5-ethoxy-2-{3-[3-(2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionylamino}-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example M57) (318 mg, 0.57 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as an off-white solid (216 mg).

Sources & evidence

ORD record
ord-625f3e4af99e43a9a08c1cbb0d5f8fb0
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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