Trifluoroacetic acid → HCID 11212343, compound

HRID 498567Notes

Reaction equation

HRID 498567 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[F:20])=[CH:10][C:9]=1[NH:21][C:22](=[O:39])[CH2:23][C:24](C1C=CC=C(C2C=CN=C(C)C=2)C=1)=O)(C)(C)C.[C:41](O)([C:43](F)(F)F)=O>C(Cl)Cl>[F:20][C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=1[C:11]1[CH:12]=[CH:13][C:8]2[N:7]=[C:24]([C:16]3[CH:17]=[CH:18][CH:19]=[C:14]([C:11]4[CH:10]=[CH:9][N:21]=[C:41]([CH3:43])[CH:12]=4)[CH:15]=3)[CH2:23][C:22](=[O:39])[NH:21][C:9]=2[CH:10]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86589273HCID 86589273, compound

Product 1

HCID 11212343HCID 11212343, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from (2′-fluoro-3-{3-[3-(2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionylamino}-biphenyl-4-yl)-carbamic acid tert-butyl ester (Example M65) (0.47 g, 0.87 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as an off-white solid (305 mg, 83%).

Sources & evidence

ORD record
ord-7e5a6872e213410991d919a6d6c72204
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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