Trifluoroacetic acid → 8-Methyl-4-[3-(2-methyl-pyridin-4-yl)-phenyl]-7-trifluoromethyl-1,3-dihydro benzo[b][1,4]diazepin-2-one

HRID 498572Notes

Reaction equation

HRID 498572 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[C:11]([CH3:18])=[CH:10][C:9]=1[NH:19][C:20](=[O:37])[CH2:21][C:22]([C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([C:30]2[CH:35]=[CH:34][N:33]=[C:32]([CH3:36])[CH:31]=2)[CH:25]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:18][C:11]1[C:12]([C:14]([F:17])([F:16])[F:15])=[CH:13][C:8]2[N:7]=[C:22]([C:24]3[CH:29]=[CH:28][CH:27]=[C:26]([C:30]4[CH:35]=[CH:34][N:33]=[C:32]([CH3:36])[CH:31]=4)[CH:25]=3)[CH2:21][C:20](=[O:37])[NH:19][C:9]=2[CH:10]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86589277(4-Methyl-2-{3-[3-(2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionylamino}-5-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester

Product 1

HCID 113732038-Methyl-4-[3-(2-methyl-pyridin-4-yl)-phenyl]-7-trifluoromethyl-1,3-dihydro benzo[b][1,4]diazepin-2-one

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from (4-methyl-2-{3-[3-(2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionylamino}-5-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example M70) (0.32 g, 0.61 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as an off white solid (120 mg, 48%).

Sources & evidence

ORD record
ord-32fd7687c4e545afbeb049744278d085
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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