Trifluoroacetic acid → HCID 22317388, compound

HRID 498633Notes

Reaction equation

HRID 498633 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][C:9]=1[NH:18][C:19](=[O:38])[CH2:20][C:21]([C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([C:29]2[C:34]([CH2:35][CH3:36])=[CH:33][N:32]=[C:31]([CH3:37])[CH:30]=2)[CH:24]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH2:35]([C:34]1[C:29]([C:25]2[CH:24]=[C:23]([C:21]3[CH2:20][C:19](=[O:38])[NH:18][C:9]4[CH:10]=[C:11]([C:14]([F:16])([F:17])[F:15])[CH:12]=[CH:13][C:8]=4[N:7]=3)[CH:28]=[CH:27][CH:26]=2)=[CH:30][C:31]([CH3:37])=[N:32][CH:33]=1)[CH3:36]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86589320HCID 86589320, compound

Product 1

HCID 22317388HCID 22317388, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from (2-{3-[3-(5-ethyl-2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionylamino}-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example M133) (0.26 g, 0.49 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as an off-white solid (170 mg, 87%).

Sources & evidence

ORD record
ord-16a8693baf974b8ab97098d7c8e9c482
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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