4,5-Dichloro-1,2-phenylenediamine → HCID 22317921, compound

HRID 498634Notes

Reaction equation

HRID 498634 reaction equation
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([NH2:9])=[C:4]([NH2:10])[CH:3]=1.C([O:15][C:16](=O)[CH2:17][C:18]([C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([C:26]2[C:31]([CH2:32][CH3:33])=[CH:30][N:29]=[C:28]([CH3:34])[CH:27]=2)[CH:21]=1)=O)(C)(C)C>C1(C)C(C)=CC=CC=1>[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]2[NH:9][C:16](=[O:15])[CH2:17][C:18]([C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([C:26]4[C:31]([CH2:32][CH3:33])=[CH:30][N:29]=[C:28]([CH3:34])[CH:27]=4)[CH:21]=3)=[N:10][C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 792974,5-Dichloro-1,2-phenylenediamineHCID 69486572HCID 69486572, compound

Product 1

HCID 22317921HCID 22317921, compound

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

The title compound was prepared from commercially available 4,5-dichloro-1,2-phenylendiamine (133 mg, 0.75 mmol) and 3-[3-(5-ethyl-2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester (Example K19) (255 mg, 0.75 mmol) in xylene (15 ml) under reflux conditions for 2 h according to the general procedure M. Obtained as a light brown solid (230 mg, 72%).

Sources & evidence

ORD record
ord-e3ddc9142e2c4f8484bba1cdd38dfa20
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

Loading…