Trifluoroacetic acid → 7-Ethoxy-4-(3-pyridin-3-yl-phenyl)-1,3-dihydro-benzo[b][1,4]diazepin-2-one

HRID 498644Notes

Reaction equation

HRID 498644 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([O:14][CH2:15][CH3:16])[CH:11]=[CH:10][C:9]=1[NH:17][C:18](=[O:34])[CH2:19][C:20](=O)[C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([C:27]2[CH:28]=[N:29][CH:30]=[CH:31][CH:32]=2)[CH:22]=1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH2:15]([O:14][C:12]1[CH:11]=[CH:10][C:9]2[NH:17][C:18](=[O:34])[CH2:19][C:20]([C:21]3[CH:26]=[CH:25][CH:24]=[C:23]([C:27]4[CH:28]=[N:29][CH:30]=[CH:31][CH:32]=4)[CH:22]=3)=[N:7][C:8]=2[CH:13]=1)[CH3:16]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86589329{5-Ethoxy-2-[3-oxo-3-(3-pyridin-3-yl-phenyl)-propionylamino]-phenyl}-carbamic acid tert-butyl ester

Product 1

HCID 223177957-Ethoxy-4-(3-pyridin-3-yl-phenyl)-1,3-dihydro-benzo[b][1,4]diazepin-2-one

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from {5-ethoxy-2-[3-oxo-3-(3-pyridin-3-yl-phenyl)-propionylamino]-phenyl}-carbamic acid tert-butyl ester (Example M144) (170 mg, 0.36 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a brown solid (84 mg, 65%).

Sources & evidence

ORD record
ord-bb166c96e9284e51afe00bfc4ce27512
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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