Acetate → 1-(4-Trifluoromethylanilino)-4-(4-pyridylmethyl)phthalazine

Participants

Role	Name	HCID	Charge
Reactant	Acetate	HCID 175	—
Reactant	4-(Trifluoromethyl)aniline	HCID 9964	—
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	1-Chloro-4-(4-pyridinylmethyl)phthalazine	HCID 1944609	—
Product	1-(4-Trifluoromethylanilino)-4-(4-pyridylmethyl)phthalazine	HCID 9929754	—

Reaction Conditions

Temperature	100 °C

Reaction Steps

A mixture of 0.511 g (2 mmol) 1-chloro-4-(4-pyridylmethyl)phthalazine and 0.746 ml (6 mmol) 4-aminobenzotrifluoride is heated for 2.5 h at 100° C. The reaction mixture is then distributed between acetate and 20% aqueous potassium carbonate solution. The title compound is obtained after further processing as described in Example 7; m.p. 205-206° C.; ESI-MS: (M+H)+=381.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06710047B2
Source dataset	uspto-grants-2004_03
ORD ID	ord-f3e4703d52224f2cbc6c760f1b82ba2a
Source note	uspto-grants-2004_03