Trifluoroacetic acid → HCID 22317186, compound

HRID 498660Notes

Reaction equation

HRID 498660 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([O:14][CH2:15][CH3:16])[C:11]([Cl:17])=[CH:10][C:9]=1[NH:18][C:19](=[O:35])[CH2:20][C:21](=O)[C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([C:28]2[CH:29]=[N:30][CH:31]=[CH:32][CH:33]=2)[CH:23]=1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[Cl:17][C:11]1[C:12]([O:14][CH2:15][CH3:16])=[CH:13][C:8]2[N:7]=[C:21]([C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([C:28]4[CH:29]=[N:30][CH:31]=[CH:32][CH:33]=4)[CH:23]=3)[CH2:20][C:19](=[O:35])[NH:18][C:9]=2[CH:10]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86589347HCID 86589347, compound

Product 1

HCID 22317186HCID 22317186, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from {4-chloro-5-ethoxy-2-[3-oxo-3-(3-pyridin-3-yl-phenyl)-propionylamino]-phenyl}-carbamic acid tert-butyl ester (Example M163) (111 mg, 0.22 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as an off-white solid (62 mg, 72%).

Sources & evidence

ORD record
ord-b21d75a4a2c944ab99c154d92e87dfd1
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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