Trifluoroacetic acid → HCID 22317828, compound

HRID 498677Notes

Reaction equation

HRID 498677 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][C:9]=1[NH:18][C:19](=[O:37])[CH2:20][C:21]([C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([C:29]2[CH:34]=[CH:33][N:32]=[C:31]([C:35]#[N:36])[CH:30]=2)[CH:24]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[O:37]=[C:19]1[CH2:20][C:21]([C:23]2[CH:24]=[C:25]([C:29]3[CH:34]=[CH:33][N:32]=[C:31]([C:35]#[N:36])[CH:30]=3)[CH:26]=[CH:27][CH:28]=2)=[N:7][C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][C:9]=2[NH:18]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86589364HCID 86589364, compound

Product 1

HCID 22317828HCID 22317828, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from (2-{3-[3-(2-cyano-pyridin-4-yl)-phenyl]-3-oxo-propionylamino}-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example M180) (304 mg, 0.58 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a white solid (147 mg, 62%).

Sources & evidence

ORD record
ord-a66af8327d6c41218054e2185b201728
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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