HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 4-{3-[7-Chloro-4-oxo-8-(2,2,2-trifluoro-ethoxy)-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl]-phenyl]-pyridine-2-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | [4-Chloro-2-{3-[3-(2-cyano-pyridin-4-yl)-phenyl]-3-oxo-propionylamino}-5-(2,2,2-trifluoro-ethoxy)-phenyl]-carbamic acid tert-butyl ester | HCID 86589367 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-{3-[7-Chloro-4-oxo-8-(2,2,2-trifluoro-ethoxy)-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl]-phenyl]-pyridine-2-carbonitrile | HCID 22317601 | — |
Reaction Steps
The title compound was prepared from [4-chloro-2-{3-[3-(2-cyano-pyridin-4-yl)-phenyl]-3-oxo-propionylamino}-5-(2,2,2-trifluoro-ethoxy)-phenyl]-carbamic acid tert-butyl ester (Example M183) (239 mg, 0.406 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a yellow solid (120 mg, 63%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06949542B2 |
| Source dataset | uspto-grants-2005_09 |
| ORD ID | ord-5dcababf976d40f990d131a29ed134a5 |
| Source note | uspto-grants-2005_09 |