Trifluoroacetic acid → 4-[3-(8-Ethyl-4-oxo-7-trifluoromethyl-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)-phenyl]-pyridine-2-carbonitrile

HRID 498689Notes

Reaction equation

HRID 498689 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([CH2:14][CH3:15])[C:11]([C:16]([F:19])([F:18])[F:17])=[CH:10][C:9]=1[NH:20][C:21](=[O:39])[CH2:22][C:23]([C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([C:31]2[CH:36]=[CH:35][N:34]=[C:33]([C:37]#[N:38])[CH:32]=2)[CH:26]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH2:14]([C:12]1[C:11]([C:16]([F:18])([F:17])[F:19])=[CH:10][C:9]2[NH:20][C:21](=[O:39])[CH2:22][C:23]([C:25]3[CH:26]=[C:27]([C:31]4[CH:36]=[CH:35][N:34]=[C:33]([C:37]#[N:38])[CH:32]=4)[CH:28]=[CH:29][CH:30]=3)=[N:7][C:8]=2[CH:13]=1)[CH3:15]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86589374(2-{3-[3-(2-Cyano-pyridin-4-yl)-phenyl]-3-oxo-propionylamino}-5-ethyl-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester

Product 1

HCID 223178354-[3-(8-Ethyl-4-oxo-7-trifluoromethyl-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)-phenyl]-pyridine-2-carbonitrile

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from (2-{3-[3-(2-cyano-pyridin-4-yl)-phenyl]-3-oxo-propionylamino}-5-ethyl-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example M190) (300 mg, 0.54 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a white solid (158 mg, 67%).

Sources & evidence

ORD record
ord-587d457a2b9d4d248441e3a0dbc11ae6
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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