Trifluoroacetic acid → HCID 22317752, compound

HRID 498695Notes

Reaction equation

HRID 498695 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([O:14][CH2:15][CH2:16][CH3:17])[C:11]([C:18]([F:21])([F:20])[F:19])=[CH:10][C:9]=1[NH:22][C:23](=[O:42])[CH2:24][C:25]([C:27]1[CH:32]=[CH:31][CH:30]=[C:29]([C:33]2[CH:34]=[N:35][C:36]([CH:39]3[CH2:41][CH2:40]3)=[CH:37][CH:38]=2)[CH:28]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH:39]1([C:36]2[N:35]=[CH:34][C:33]([C:29]3[CH:28]=[C:27]([C:25]4[CH2:24][C:23](=[O:42])[NH:22][C:9]5[CH:10]=[C:11]([C:18]([F:19])([F:20])[F:21])[C:12]([O:14][CH2:15][CH2:16][CH3:17])=[CH:13][C:8]=5[N:7]=4)[CH:32]=[CH:31][CH:30]=3)=[CH:38][CH:37]=2)[CH2:40][CH2:41]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86589380HCID 86589380, compound

Product 1

HCID 22317752HCID 22317752, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from (2-{3-[3-(6-cyclopropyl-pyridin-3-yl)-phenyl]-3-oxo-propionylamino}-5-propoxy-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example M196) (362 mg, 0.59 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as an off-white solid (153 mg, 54%).

Sources & evidence

ORD record
ord-73ebfd67310c40d2b124949c3dec38eb
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

Loading…