Trifluoroacetic acid → HCID 22317996, compound

HRID 498698Notes

Reaction equation

HRID 498698 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([O:14][CH2:15][CH2:16][CH3:17])[C:11]([C:18]([F:21])([F:20])[F:19])=[CH:10][C:9]=1[NH:22][C:23](=[O:41])[CH2:24][C:25]([C:27]1[CH:32]=[CH:31][CH:30]=[C:29]([C:33]2[CH:38]=[C:37]([CH3:39])[N:36]=[C:35]([CH3:40])[CH:34]=2)[CH:28]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:40][C:35]1[CH:34]=[C:33]([C:29]2[CH:28]=[C:27]([C:25]3[CH2:24][C:23](=[O:41])[NH:22][C:9]4[CH:10]=[C:11]([C:18]([F:21])([F:19])[F:20])[C:12]([O:14][CH2:15][CH2:16][CH3:17])=[CH:13][C:8]=4[N:7]=3)[CH:32]=[CH:31][CH:30]=2)[CH:38]=[C:37]([CH3:39])[N:36]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86589383HCID 86589383, compound

Product 1

HCID 22317996HCID 22317996, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from (2-{3-[3-(2,6-dimethyl-pyridin-4-yl)-phenyl]-3-oxo-propionylamino}-5-propoxy-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example M199) (319 mg, 0.545 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a light yellow solid (172 mg, 68%).

Sources & evidence

ORD record
ord-aeb8d3735787450989d651c2c1b05ab2
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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