Trifluoroacetic acid → HCID 22317951, compound

HRID 498699Notes

Reaction equation

HRID 498699 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][C:9]=1[NH:18][C:19](=[O:38])[CH2:20][C:21]([C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([C:29]2[C:30]([CH:35]3[CH2:37][CH2:36]3)=[N:31][CH:32]=[CH:33][CH:34]=2)[CH:24]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH:35]1([C:30]2[C:29]([C:25]3[CH:24]=[C:23]([C:21]4[CH2:20][C:19](=[O:38])[NH:18][C:9]5[CH:10]=[C:11]([C:14]([F:16])([F:17])[F:15])[CH:12]=[CH:13][C:8]=5[N:7]=4)[CH:28]=[CH:27][CH:26]=3)=[CH:34][CH:33]=[CH:32][N:31]=2)[CH2:37][CH2:36]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86589384HCID 86589384, compound

Product 1

HCID 22317951HCID 22317951, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from (2-{3-[3-(2-cyclopropyl-pyridin-3-yl)-phenyl]-3-oxo-propionylamino}-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example M200) (223 mg, 0.413 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a light yellow solid (107 mg, 61%).

Sources & evidence

ORD record
ord-6787fe6b85f34d12abd32f75e95fcd76
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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