Trifluoroacetic acid → HCID 22317233, compound

HRID 498703Notes

Reaction equation

HRID 498703 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([CH2:14][CH2:15][CH3:16])[C:11]([C:17]([F:20])([F:19])[F:18])=[CH:10][C:9]=1[NH:21][C:22](=[O:41])[CH2:23][C:24]([C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([C:32]2[CH:33]=[N:34][C:35]([CH:38]3[CH2:40][CH2:39]3)=[CH:36][CH:37]=2)[CH:27]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH:38]1([C:35]2[N:34]=[CH:33][C:32]([C:28]3[CH:27]=[C:26]([C:24]4[CH2:23][C:22](=[O:41])[NH:21][C:9]5[CH:10]=[C:11]([C:17]([F:20])([F:18])[F:19])[C:12]([CH2:14][CH2:15][CH3:16])=[CH:13][C:8]=5[N:7]=4)[CH:31]=[CH:30][CH:29]=3)=[CH:37][CH:36]=2)[CH2:39][CH2:40]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86589388HCID 86589388, compound

Product 1

HCID 22317233HCID 22317233, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from (2-{3-[3-(6-cyclopropyl-pyridin-3-yl)-phenyl]-3-oxo-propionylamino}-5-propyl-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example M204) (266 mg, 0.46 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a light yellow solid (75 mg, 35%).

Sources & evidence

ORD record
ord-499c13677eb34157b30b84a5e2a9f259
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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