Trifluoroacetic acid → HCID 22317518, compound

HRID 498711Notes

Reaction equation

HRID 498711 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12](OCC(F)(F)F)[C:11]([C:20]([F:23])([F:22])[F:21])=[CH:10][C:9]=1[NH:24][C:25](=[O:42])[CH2:26][C:27]([C:29]1[CH:34]=[CH:33][CH:32]=[C:31]([C:35]2[CH:36]=[N:37][CH:38]=[CH:39][C:40]=2[CH3:41])[CH:30]=1)=O)(C)(C)C.[C:44](O)([C:46]([F:49])([F:48])[F:47])=[O:45]>C(Cl)Cl>[CH3:41][C:40]1[CH:39]=[CH:38][N:37]=[CH:36][C:35]=1[C:31]1[CH:30]=[C:29]([C:27]2[CH2:26][C:25](=[O:42])[NH:24][C:9]3[CH:10]=[C:11]([C:20]([F:23])([F:22])[F:21])[C:12]([O:45][CH2:44][C:46]([F:49])([F:48])[F:47])=[CH:13][C:8]=3[N:7]=2)[CH:34]=[CH:33][CH:32]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86589396[2-{3-[3-(4-Methyl-pyridin-3-yl)-phenyl]-3-oxo-propionylamino}-5-(2,2,2-trifluoro-ethoxy)-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester

Product 1

HCID 22317518HCID 22317518, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from [2-{3-[3-(4-methyl-pyridin-3-yl)-phenyl]-3-oxo-propionylamino}-5-(2,2,2-trifluoro-ethoxy)-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester (Example M212) (304 mg, 0.545 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as an off-white solid (180 mg, 60%).

Sources & evidence

ORD record
ord-f64be58e23b745aca7823620f7ecbfbb
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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