Trifluoroacetic acid → HCID 22317838, compound

HRID 498723Notes

Reaction equation

HRID 498723 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12](C=C)[C:11]([C:16](F)(F)F)=[CH:10][C:9]=1[NH:20][C:21](=[O:38])[CH2:22][C:23]([C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([C:31]2[CH:36]=[CH:35][N:34]=[C:33]([CH3:37])[CH:32]=2)[CH:26]=1)=O)(C)(C)C.[C:40](O)([C:42]([F:45])([F:44])[F:43])=O>C(Cl)Cl>[CH3:37][C:33]1[CH:32]=[C:31]([C:27]2[CH:26]=[C:25]([C:23]3[CH2:22][C:21](=[O:38])[NH:20][C:9]4[CH:10]=[C:40]([C:42]([F:45])([F:44])[F:43])[C:12]([CH:11]=[CH2:16])=[CH:13][C:8]=4[N:7]=3)[CH:30]=[CH:29][CH:28]=2)[CH:36]=[CH:35][N:34]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86589408(2-{3-[3-(2-Methyl-pyridin-4-yl)-phenyl]-3-oxo-propionylamino}-4-trifluoromethyl-5-vinyl-phenyl)-carbamic acid tert-butyl ester

Product 1

HCID 22317838HCID 22317838, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from (2-{3-[3-(2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionylamino}-4-trifluoromethyl-5-vinyl-phenyl)-carbamic acid tert-butyl ester (Example M224) (300 mg, 0.56 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a light brown solid (133 mg, 56%).

Sources & evidence

ORD record
ord-846d04879c2e4d47847bb257d14521e3
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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