Trifluoroacetic acid → HCID 22317945, compound

HRID 498726Notes

Reaction equation

HRID 498726 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([O:14][CH2:15][C:16]([F:19])([F:18])[F:17])[C:11]([C:20]([F:23])([F:22])[F:21])=[CH:10][C:9]=1[NH:24][C:25](=[O:45])[CH2:26][C:27]([C:29]1[CH:34]=[CH:33][CH:32]=[C:31]([C:35]2[CH:36]=[N:37][C:38]([CH:42]3[CH2:44][CH2:43]3)=[CH:39][C:40]=2[CH3:41])[CH:30]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH:42]1([C:38]2[N:37]=[CH:36][C:35]([C:31]3[CH:30]=[C:29]([C:27]4[CH2:26][C:25](=[O:45])[NH:24][C:9]5[CH:10]=[C:11]([C:20]([F:21])([F:22])[F:23])[C:12]([O:14][CH2:15][C:16]([F:19])([F:17])[F:18])=[CH:13][C:8]=5[N:7]=4)[CH:34]=[CH:33][CH:32]=3)=[C:40]([CH3:41])[CH:39]=2)[CH2:43][CH2:44]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86589412HCID 86589412, compound

Product 1

HCID 22317945HCID 22317945, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from [2-{3-[3-(6-cyclopropyl-4-methyl-pyridin-3-yl)-phenyl]-3-oxo-propionylamino}-5-(2,2,2-trifluoro-ethoxy)-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester (Example M228) (305 mg, 0.47 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as an off-white solid (206 mg, 82%).

Sources & evidence

ORD record
ord-4c9b9b06315942db871d1aa2637fec09
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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