Trifluoroacetic acid → 4-[3-(4,6-Dimethyl-pyridin-3-yl)-phenyl]-7-ethoxy-8-trifluoromethyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one

HRID 498729Notes

Reaction equation

HRID 498729 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([O:14][CH2:15][CH3:16])[C:11]([C:17]([F:20])([F:19])[F:18])=[CH:10][C:9]=1[NH:21][C:22](=[O:40])[CH2:23][C:24]([C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([C:32]2[CH:33]=[N:34][C:35]([CH3:39])=[CH:36][C:37]=2[CH3:38])[CH:27]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:38][C:37]1[CH:36]=[C:35]([CH3:39])[N:34]=[CH:33][C:32]=1[C:28]1[CH:27]=[C:26]([C:24]2[CH2:23][C:22](=[O:40])[NH:21][C:9]3[CH:10]=[C:11]([C:17]([F:20])([F:19])[F:18])[C:12]([O:14][CH2:15][CH3:16])=[CH:13][C:8]=3[N:7]=2)[CH:31]=[CH:30][CH:29]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86589416(2-{3-[3-(4,6-Dimethyl-pyridin-3-yl)-phenyl]-3-oxo-propionylamino}-5-ethoxy-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester

Product 1

HCID 223172814-[3-(4,6-Dimethyl-pyridin-3-yl)-phenyl]-7-ethoxy-8-trifluoromethyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from (2-{3-[3-(4,6-dimethyl-pyridin-3-yl)-phenyl]-3-oxo-propionylamino}-5-ethoxy-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example M232) (340 mg, 0.595 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a white solid (148 mg, 55%).

Sources & evidence

ORD record
ord-d5dbef1483aa4bbb9b83d5d549d2c64e
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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