Trifluoroacetic acid → HCID 22317758, compound

HRID 498735Notes

Reaction equation

HRID 498735 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([O:14][CH2:15][CH3:16])[C:11]([C:17]([F:20])([F:19])[F:18])=[CH:10][C:9]=1[NH:21][C:22](=[O:42])[CH2:23][C:24]([C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([C:32]2[CH:37]=[C:36]([CH3:38])[N:35]=[C:34]([CH:39]3[CH2:41][CH2:40]3)[CH:33]=2)[CH:27]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH:39]1([C:34]2[CH:33]=[C:32]([C:28]3[CH:27]=[C:26]([C:24]4[CH2:23][C:22](=[O:42])[NH:21][C:9]5[CH:10]=[C:11]([C:17]([F:20])([F:19])[F:18])[C:12]([O:14][CH2:15][CH3:16])=[CH:13][C:8]=5[N:7]=4)[CH:31]=[CH:30][CH:29]=3)[CH:37]=[C:36]([CH3:38])[N:35]=2)[CH2:41][CH2:40]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86589422HCID 86589422, compound

Product 1

HCID 22317758HCID 22317758, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from (2-{3-[3-(2-cyclopropyl-6-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionylamino}-5-ethoxy-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example M238) (244 mg, 0.41 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as an off-white solid (150 mg, 76%).

Sources & evidence

ORD record
ord-758bfec41e1d466481e1813abc874ca0
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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