Trifluoroacetic acid → HCID 22317330, compound

HRID 498736Notes

Reaction equation

HRID 498736 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12](OCC(F)(F)F)[C:11](C(F)(F)F)=[CH:10][C:9]=1[NH:24][C:25](=[O:45])[CH2:26][C:27]([C:29]1[CH:34]=[CH:33][CH:32]=[C:31]([C:35]2[CH:40]=[C:39]([CH3:41])[N:38]=[C:37]([CH:42]3[CH2:44][CH2:43]3)[CH:36]=2)[CH:30]=1)=O)(C)(C)C.[C:47](O)([C:49]([F:52])([F:51])[F:50])=[O:48]>C(Cl)Cl>[CH:42]1([C:37]2[CH:36]=[C:35]([C:31]3[CH:30]=[C:29]([C:27]4[CH2:26][C:25](=[O:45])[NH:24][C:9]5[CH:10]=[C:11]([C:49]([F:52])([F:51])[F:50])[C:12]([O:48][CH2:47][C:49]([F:52])([F:51])[F:50])=[CH:13][C:8]=5[N:7]=4)[CH:34]=[CH:33][CH:32]=3)[CH:40]=[C:39]([CH3:41])[N:38]=2)[CH2:43][CH2:44]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86589423HCID 86589423, compound

Product 1

HCID 22317330HCID 22317330, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from [2-{3-[3-(2-cyclopropyl-6-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionylamino}-5-(2,2,2-trifluoro-ethoxy)-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester (Example M239) (308 mg, 0.47 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as an off-white solid (199 mg, 79%).

Sources & evidence

ORD record
ord-646b715d257045778aab251e126b5c23
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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